1tsl: Difference between revisions

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<StructureSection load='1tsl' size='340' side='right'caption='[[1tsl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1tsl' size='340' side='right'caption='[[1tsl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1tsl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSL FirstGlance]. <br>
<table><tr><td colspan='2'>[[1tsl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A15:3-3+-DICHLOROPHENOL-1,8-3H-BENZO[DE]ISOCHROMEN-1-ONE'>A15</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A15:3-3+-DICHLOROPHENOL-1,8-3H-BENZO[DE]ISOCHROMEN-1-ONE'>A15</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsl OCA], [https://pdbe.org/1tsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsl RCSB], [https://www.ebi.ac.uk/pdbsum/1tsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsl OCA], [https://pdbe.org/1tsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsl RCSB], [https://www.ebi.ac.uk/pdbsum/1tsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.  
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus a von freudenreich 1890]]
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Stout TJ]]
[[Category: Stout, T J]]
[[Category: Stroud RM]]
[[Category: Stroud, R M]]
[[Category: Antibiotic]]
[[Category: Methyltransferase]]
[[Category: Species specificity]]
[[Category: Structure-based drug design]]

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