1mff: Difference between revisions

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<StructureSection load='1mff' size='340' side='right'caption='[[1mff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1mff' size='340' side='right'caption='[[1mff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1mff]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFF FirstGlance]. <br>
<table><tr><td colspan='2'>[[1mff]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFF FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mff OCA], [https://pdbe.org/1mff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mff RCSB], [https://www.ebi.ac.uk/pdbsum/1mff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mff ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mff OCA], [https://pdbe.org/1mff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mff RCSB], [https://www.ebi.ac.uk/pdbsum/1mff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mff ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MIF_MOUSE MIF_MOUSE]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).  
[https://www.uniprot.org/uniprot/MIF_MOUSE MIF_MOUSE] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Hackert, M L]]
[[Category: Hackert ML]]
[[Category: Stamps, S L]]
[[Category: Stamps SL]]
[[Category: Taylor, A B]]
[[Category: Taylor AB]]
[[Category: Wang, S C]]
[[Category: Wang SC]]
[[Category: Whitman, C P]]
[[Category: Whitman CP]]
[[Category: Cytokine]]
[[Category: Inflammatory response]]
[[Category: Macrophage]]
[[Category: Tautomerase]]

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