1iol: Difference between revisions

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[[Image:1iol.gif|left|200px]]<br />
<applet load="1iol" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1iol, resolution 2.3&Aring;" />
'''ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED 17-BETA-ESTRADIOL'''<br />


==About this Structure==
==ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED 17-BETA-ESTRADIOL==
1IOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EST as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] Structure known Active Site: S1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IOL OCA].  
<StructureSection load='1iol' size='340' side='right'caption='[[1iol]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1iol]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iol OCA], [https://pdbe.org/1iol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iol RCSB], [https://www.ebi.ac.uk/pdbsum/1iol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iol ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/1iol_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iol ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol., Azzi A, Rehse PH, Zhu DW, Campbell RL, Labrie F, Lin SX, Nat Struct Biol. 1996 Aug;3(8):665-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8756321 8756321]
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
[[Category: Estradiol 17-beta-dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Azzi, A.]]
[[Category: Azzi A]]
[[Category: Campbell, R.L.]]
[[Category: Campbell RL]]
[[Category: Labrie, F.]]
[[Category: Labrie F]]
[[Category: Lin, S.X.]]
[[Category: Lin S-X]]
[[Category: Rehse, P.H.]]
[[Category: Rehse PH]]
[[Category: Zhu, D.W.]]
[[Category: Zhu D-W]]
[[Category: EST]]
[[Category: oxidoreductase]]
[[Category: short-chain dehydrogenase]]
[[Category: steroid biosynthesis]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 16:39:58 2007''

Latest revision as of 09:26, 9 August 2023

ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED 17-BETA-ESTRADIOLESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED 17-BETA-ESTRADIOL

Structural highlights

1iol is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DHB1_HUMAN Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1iol, resolution 2.30Å

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