1iao: Difference between revisions

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-[[Image:1iao.png|left|200px]]
-{{STRUCTURE_1iao|  PDB=1iao  |  SCENE=  }}
+==CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339==
+<StructureSection load='1iao' size='340' side='right'caption='[[1iao]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1iao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IAO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iao OCA], [https://pdbe.org/1iao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iao RCSB], [https://www.ebi.ac.uk/pdbsum/1iao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iao ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA2D_MOUSE HA2D_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/1iao_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iao ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We have determined the structures of I-Ad covalently linked to an ovalbumin peptide (OVA323-339) and to an influenza virus hemagglutinin peptide (HA126-138). The floor of the peptide-binding groove contains an unusual beta bulge, not seen in I-E and DR structures, that affects numerous interactions between the alpha and beta chains and bound peptide. Unlike other MHC-peptide complexes, the peptides do not insert any large anchor residues into the binding pockets of the shallow I-Ad binding groove. The previously identified six-residue "core" binding motif of I-Ad occupies only the P4 to P9 pockets, implying that specificity of T cell receptor recognition of I-Ad-peptide complexes can be accomplished by peptides that only partially fill the MHC groove.
-===CLASS II MHC I-AD IN COMPLEX WITH OVALBUMIN PEPTIDE 323-339===
+Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.,Scott CA, Peterson PA, Teyton L, Wilson IA Immunity. 1998 Mar;8(3):319-29. PMID:9529149<ref>PMID:9529149</ref>
-{{ABSTRACT_PUBMED_9529149}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1iao" style="background-color:#fffaf0;"></div>
-[[1iao]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAO OCA].
+== References ==
+<references/>
-==See Also==
+__TOC__
-*[[Homology modeling servers|Homology modeling servers]]
+</StructureSection>
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:009529149</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Peterson, P A.]]
+[[Category: Peterson PA]]
-[[Category: Scott, C A.]]
+[[Category: Scott CA]]
-[[Category: Teyton, L.]]
+[[Category: Teyton L]]
-[[Category: Wilson, I A.]]
+[[Category: Wilson IA]]
-[[Category: Class ii mhc]]
-[[Category: I-a]]
-[[Category: Mhc ii]]
-[[Category: Ovalbumin peptide]]