1i7x: Difference between revisions

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-[[Image:1i7x.png|left|200px]]
-<!--
+==BETA-CATENIN/E-CADHERIN COMPLEX==
-The line below this paragraph, containing "STRUCTURE_1i7x", creates the "Structure Box" on the page.
+<StructureSection load='1i7x' size='340' side='right'caption='[[1i7x]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1i7x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The March 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cadherin''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_3 10.2210/rcsb_pdb/mom_2008_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I7X FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7x OCA], [https://pdbe.org/1i7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i7x RCSB], [https://www.ebi.ac.uk/pdbsum/1i7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i7x ProSAT]</span></td></tr>
-{{STRUCTURE_1i7x|  PDB=1i7x  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i7/1i7x_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i7x ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.
-'''BETA-CATENIN/E-CADHERIN COMPLEX'''
+The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.,Huber AH, Weis WI Cell. 2001 May 4;105(3):391-402. PMID:11348595<ref>PMID:11348595</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1i7x" style="background-color:#fffaf0;"></div>
-{{ABSTRACT_11348595}}
+==See Also==
+*[[Cadherin 3D structures|Cadherin 3D structures]]
-==About this Structure==
+*[[Catenin 3D structures|Catenin 3D structures]]
-I7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA].
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cadherin]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Protein complex]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Huber, A H.]]
+[[Category: Huber AH]]
-[[Category: Weis, W I.]]
+[[Category: Weis WI]]
-[[Category: Armadillo repeat]]
-[[Category: Beta-catenin]]
-[[Category: Cell adhesion]]
-[[Category: E-cadherin]]
-[[Category: Extended interface]]
-[[Category: Protein-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:32:01 2008''