1g62: Difference between revisions

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-[[Image:1g62.gif|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1g62", creates the "Structure Box" on the page.
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-{{STRUCTURE_1g62|  PDB=1g62  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6'''
+==CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6==
+<StructureSection load='1g62' size='340' side='right'caption='[[1g62]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1g62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G62 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g62 OCA], [https://pdbe.org/1g62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g62 RCSB], [https://www.ebi.ac.uk/pdbsum/1g62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g62 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1g62 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IF6_YEAST IF6_YEAST] Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.<ref>PMID:10085284</ref> <ref>PMID:11779510</ref> <ref>PMID:11238882</ref> <ref>PMID:17353896</ref> <ref>PMID:18256024</ref> <ref>PMID:11101899</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g62_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g62 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
-==Overview==
+Crystal structures of ribosome anti-association factor IF6.,Groft CM, Beckmann R, Sali A, Burley SK Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899<ref>PMID:11101899</ref>
-Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-G62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA].
+</div>
+<div class="pdbe-citations 1g62" style="background-color:#fffaf0;"></div>
-==Reference==
+==See Also==
-Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101899 11101899]
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Beckmann R]]
-[[Category: Beckmann, R.]]
+[[Category: Burley SK]]
-[[Category: Burley, S K.]]
+[[Category: Groft CM]]
-[[Category: Groft, C M.]]
+[[Category: Sali A]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
-[[Category: Sali, A.]]
-[[Category: Alpha-beta barrel]]
-[[Category: New york structural genomix research consortium]]
-[[Category: Nysgxrc]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-[[Category: Subdomain]]
-[[Category: Velcro closure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:10:57 2008''