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[[Image:1f0l.jpg|left|200px]]


{{Structure
==1.55 ANGSTROM CRYSTAL STRUCTURE OF WILD TYPE DIPHTHERIA TOXIN==
|PDB= 1f0l |SIZE=350|CAPTION= <scene name='initialview01'>1f0l</scene>, resolution 1.55&Aring;
<StructureSection load='1f0l' size='340' side='right'caption='[[1f0l]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
|SITE= <scene name='pdbsite=CAT:Refers+To+Catalytic+Site'>CAT</scene> and <scene name='pdbsite=CBT:Refers+To+Catalytic+Site'>CBT</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=APU:ADENYLYL-3'-5'-PHOSPHO-URIDINE-3'-MONOPHOSPHATE'>APU</scene>
<table><tr><td colspan='2'>[[1f0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0L FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APU:ADENYLYL-3-5-PHOSPHO-URIDINE-3-MONOPHOSPHATE'>APU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0l OCA], [https://pdbe.org/1f0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0l RCSB], [https://www.ebi.ac.uk/pdbsum/1f0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>


'''1.55 ANGSTROM CRYSTAL STRUCTURE OF WILD TYPE DIPHTHERIA TOXIN'''
==See Also==
 
*[[Diphtheria toxin|Diphtheria toxin]]
 
== References ==
==About this Structure==
<references/>
1F0L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0L OCA].
__TOC__
</StructureSection>
[[Category: Corynebacterium diphtheriae]]
[[Category: Corynebacterium diphtheriae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Eisenberg, D.]]
[[Category: Eisenberg D]]
[[Category: Steere, B.]]
[[Category: Steere B]]
[[Category: APU]]
[[Category: CL]]
[[Category: adp-ribosylation]]
[[Category: bacterial toxin]]
[[Category: transmembrane]]
 
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