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==ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN==
==ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN==
<StructureSection load='1eui' size='340' side='right' caption='[[1eui]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='1eui' size='340' side='right'caption='[[1eui]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1eui]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bppb2 Bppb2] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1EUI FirstGlance]. <br>
<table><tr><td colspan='2'>[[1eui]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_phage_PBS2 Bacillus phage PBS2] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EUI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1eui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eui OCA], [http://pdbe.org/1eui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1eui RCSB], [http://www.ebi.ac.uk/pdbsum/1eui PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eui OCA], [https://pdbe.org/1eui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eui RCSB], [https://www.ebi.ac.uk/pdbsum/1eui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eui ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UNG_ECOLI UNG_ECOLI]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_00148] [[http://www.uniprot.org/uniprot/UNGI_BPPB2 UNGI_BPPB2]] This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.
[https://www.uniprot.org/uniprot/UNG_ECOLI UNG_ECOLI] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.[HAMAP-Rule:MF_00148]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/1eui_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/1eui_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[DNA glycosylase|DNA glycosylase]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
*[[Uracil glycosylate inhibitor|Uracil glycosylate inhibitor]]
*[[Uracil glycosylase inhibitor|Uracil glycosylase inhibitor]]
*[[Uracil-DNA glycosylase|Uracil-DNA glycosylase]]
*[[Uracil-DNA glycosylase inhibitor|Uracil-DNA glycosylase inhibitor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bppb2]]
[[Category: Bacillus phage PBS2]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Handa, P]]
[[Category: Large Structures]]
[[Category: Purnapatre, K]]
[[Category: Handa P]]
[[Category: Ravishankar, R]]
[[Category: Purnapatre K]]
[[Category: Roy, S]]
[[Category: Ravishankar R]]
[[Category: Sagar, M B]]
[[Category: Roy S]]
[[Category: Varshney, U]]
[[Category: Sagar MB]]
[[Category: Vijayan, M]]
[[Category: Varshney U]]
[[Category: Base excision]]
[[Category: Vijayan M]]
[[Category: Dna repair]]
[[Category: Glycosylase]]
[[Category: Inhibitor]]

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