1ed3: Difference between revisions

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-{{Seed}}
-[[Image:1ed3.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.==
-The line below this paragraph, containing "STRUCTURE_1ed3", creates the "Structure Box" on the page.
+<StructureSection load='1ed3' size='340' side='right'caption='[[1ed3]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ed3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ED3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed3 OCA], [https://pdbe.org/1ed3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ed3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ed3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ed3 ProSAT]</span></td></tr>
-{{STRUCTURE_1ed3|  PDB=1ed3  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA12_RAT HA12_RAT] Involved in the presentation of foreign antigens to the immune system.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/1ed3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ed3 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen. The antigenic structure of MTF-E was unpredictable due to its extraordinary length and two arginines that could serve as potential anchor residues. The crystal structure of RT1-Aa-MTF-E at 2.55 A shows that both peptide termini are anchored, as in other class I molecules, but the central residues in two independent pMHC complexes adopt completely different bulged conformations based on local environment. The MTF-E epitope is fully exposed within the putative T cell receptor (TCR) footprint. The flexibility demonstrated by the MTF-E structures illustrates how different TCRs may be raised against chemically identical, but structurally dissimilar, pMHC complexes.
-===CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.===
+Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa.,Speir JA, Stevens J, Joly E, Butcher GW, Wilson IA Immunity. 2001 Jan;14(1):81-92. PMID:11163232<ref>PMID:11163232</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ed3" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_11163232}}, adds the Publication Abstract to the page
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 11163232 is the PubMed ID number.
+*[[MHC 3D structures|MHC 3D structures]]
--->
+*[[MHC I 3D structures|MHC I 3D structures]]
-{{ABSTRACT_PUBMED_11163232}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-ED3 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ED3 OCA].
+</StructureSection>
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:11163232</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
-[[Category: Butcher, G W.]]
+[[Category: Butcher GW]]
-[[Category: Joly, E.]]
+[[Category: Joly E]]
-[[Category: Speir, J A.]]
+[[Category: Speir JA]]
-[[Category: Stevens, J.]]
+[[Category: Stevens J]]
-[[Category: Wilson, I A.]]
+[[Category: Wilson IA]]
-[[Category: Cell surface receptor]]
-[[Category: Cellular immunity]]
-[[Category: Immunology]]
-[[Category: Major histocompatibility complex]]
-[[Category: Mhc]]
-[[Category: Peptide antigen presentation]]
-[[Category: Rat minor histocompatibility complex]]
-[[Category: T cell receptor ligand]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:48:43 2009''