8jpd: Difference between revisions
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==Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes== | |||
<StructureSection load='8jpd' size='340' side='right'caption='[[8jpd]], [[Resolution|resolution]] 2.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JPD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.81Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jpd OCA], [https://pdbe.org/8jpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jpd RCSB], [https://www.ebi.ac.uk/pdbsum/8jpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jpd ProSAT]</span></td></tr> | ||
[[Category: Duan | </table> | ||
[[Category: | == Function == | ||
[[Category: Liu | [https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). | ||
[[Category: Yuan | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Duan J]] | |||
[[Category: Ji Y]] | |||
[[Category: Liu H]] | |||
[[Category: Xu HE]] | |||
[[Category: Yuan Q]] | |||
[[Category: Zhao F]] | |||
Latest revision as of 08:30, 9 August 2023
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexesFocused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Structural highlights
FunctionARBK1_BOVIN Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). |
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