Testosterone: Difference between revisions
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='98/980335/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='98/980335/Cv/1'> | ||
Testosterone is the primary male sex hormone and anabolic steroid in males.<ref name="a3">[https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/performance-enhancing-drugs/art-20046134|"Understanding the risks of performance-enhancing drugs".] Mayo Clinic. Retrieved December 30, 2019.</ref> In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased sex drive, the inclination to impress partners and other courting behaviors.<ref name="a4">PMID:3549275</ref> | Testosterone is the primary male sex hormone and anabolic steroid in males.<ref name="a3">[https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/performance-enhancing-drugs/art-20046134|"Understanding the risks of performance-enhancing drugs".] Mayo Clinic. Retrieved December 30, 2019.</ref> In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased sex drive, the inclination to impress partners and other courting behaviors.<ref name="a4">PMID:3549275</ref> See also [https://en.wikipedia.org/wiki/Testosterone| Testosterone]. | ||
Testosterone is a steroid from the androstane class. It exerts its action through binding to and activation of the [[androgen receptor]]. Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.<ref>PMID:18805694</ref> Water molecules are shown as red spheres. <scene name='89/895670/Cv/6'>Human androgen receptor bound to testosterone</scene> ([[2ylo]]). | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 15:05, 7 August 2023
Testosterone is the primary male sex hormone and anabolic steroid in males.[1] In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased sex drive, the inclination to impress partners and other courting behaviors.[2] See also Testosterone. Testosterone is a steroid from the androstane class. It exerts its action through binding to and activation of the androgen receptor. Ligand binding domain (LBD) containing an which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.[3] Water molecules are shown as red spheres. (2ylo).
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ReferencesReferences
- ↑ "Understanding the risks of performance-enhancing drugs". Mayo Clinic. Retrieved December 30, 2019.
- ↑ Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev. 1987 Feb;8(1):1-28. PMID:3549275 doi:10.1210/edrv-8-1-1
- ↑ Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5567-70. Epub 2008 Sep 5. PMID:18805694 doi:10.1016/j.bmcl.2008.09.002