5gnt: Difference between revisions

Latest revision as of 14:37, 2 August 2023

BDLP-like folding of Mitofusin 1BDLP-like folding of Mitofusin 1

Structural highlights

5gnt is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.665Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MFN1_HUMAN Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.^[1] ^[2] ^[3] ^[4]

References

↑ Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci. 2001 Mar;114(Pt 5):867-74. PMID:11181170
↑ Legros F, Lombes A, Frachon P, Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell. 2002 Dec;13(12):4343-54. PMID:12475957 doi:http://dx.doi.org/10.1091/mbc.E02-06-0330
↑ Santel A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2763-74. Epub 2003 May 20. PMID:12759376 doi:http://dx.doi.org/10.1242/jcs.00479
↑ Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem. 2013 Sep 20;288(38):27584-93. doi: 10.1074/jbc.M113.479873. Epub, 2013 Aug 6. PMID:23921378 doi:http://dx.doi.org/10.1074/jbc.M113.479873

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OCA

[1] Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci. 2001 Mar;114(Pt 5):867-74. PMID:11181170

[2] Legros F, Lombes A, Frachon P, Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell. 2002 Dec;13(12):4343-54. PMID:12475957 doi:http://dx.doi.org/10.1091/mbc.E02-06-0330

[3] Santel A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci. 2003 Jul 1;116(Pt 13):2763-74. Epub 2003 May 20. PMID:12759376 doi:http://dx.doi.org/10.1242/jcs.00479

[4] Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem. 2013 Sep 20;288(38):27584-93. doi: 10.1074/jbc.M113.479873. Epub, 2013 Aug 6. PMID:23921378 doi:http://dx.doi.org/10.1074/jbc.M113.479873

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
 ==BDLP-like folding of Mitofusin 1==
-<StructureSection load='5gnt' size='340' side='right' caption='[[5gnt]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
+<StructureSection load='5gnt' size='340' side='right'caption='[[5gnt]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5gnt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5gnt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNT FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.665&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gns|5gns]], [[5gnr|5gnr]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnt OCA], [http://pdbe.org/5gnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gnt RCSB], [http://www.ebi.ac.uk/pdbsum/5gnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnt ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnt OCA], [https://pdbe.org/5gnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gnt RCSB], [https://www.ebi.ac.uk/pdbsum/5gnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref>
+[https://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Hu, J]]
+[[Category: Homo sapiens]]
-[[Category: Lou, Z]]
+[[Category: Large Structures]]
-[[Category: Ming, Z]]
+[[Category: Hu J]]
-[[Category: Rao, Z]]
+[[Category: Lou Z]]
-[[Category: Yan, L]]
+[[Category: Ming Z]]
-[[Category: Yu, C]]
+[[Category: Rao Z]]
-[[Category: Bdlp-like folding]]
+[[Category: Yan L]]
-[[Category: Hydrolase]]
+[[Category: Yu C]]
-[[Category: Mitofusin 1]]

5gnt: Difference between revisions

Latest revision as of 14:37, 2 August 2023

BDLP-like folding of Mitofusin 1BDLP-like folding of Mitofusin 1

Structural highlights

Function

References

Contents

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5gnt: Difference between revisions

Latest revision as of 14:37, 2 August 2023

BDLP-like folding of Mitofusin 1BDLP-like folding of Mitofusin 1

Structural highlights

Function

References

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