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New page: '''Unreleased structure''' The entry 5gnr is ON HOLD Authors: Yan, L., Yu, C., Ming, Z., Lou, Z., Rao, Z., Hu, J. Description: the structure of mini-MFN1 K88A in complex with GDP [[Cat... |
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==the structure of mini-MFN1 K88A in complex with GDP== | |||
<StructureSection load='5gnr' size='340' side='right'caption='[[5gnr]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gnr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnr OCA], [https://pdbe.org/5gnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gnr RCSB], [https://www.ebi.ac.uk/pdbsum/5gnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnr ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MFN1_HUMAN MFN1_HUMAN] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:11181170</ref> <ref>PMID:12475957</ref> <ref>PMID:12759376</ref> <ref>PMID:23921378</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hu J]] | |||
[[Category: Lou Z]] | |||
[[Category: Ming Z]] | |||
[[Category: Rao Z]] | |||
[[Category: Yan L]] | |||
[[Category: Yu C]] | |||
Latest revision as of 14:37, 2 August 2023
the structure of mini-MFN1 K88A in complex with GDPthe structure of mini-MFN1 K88A in complex with GDP
Structural highlights
FunctionMFN1_HUMAN Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.[1] [2] [3] [4] References
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