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==Crystal structure of Sulfolobus solfataricus Diphosphomevalonate decarboxylase in complex with ADP==
==Crystal structure of Sulfolobus solfataricus Diphosphomevalonate decarboxylase in complex with ADP==
<StructureSection load='5gme' size='340' side='right' caption='[[5gme]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5gme' size='340' side='right'caption='[[5gme]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5gme]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GME FirstGlance]. <br>
<table><tr><td colspan='2'>[[5gme]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GME FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DP6:(3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC+ACID'>DP6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gmd|5gmd]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DP6:(3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC+ACID'>DP6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphomevalonate_decarboxylase Diphosphomevalonate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.33 4.1.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gme OCA], [https://pdbe.org/5gme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gme RCSB], [https://www.ebi.ac.uk/pdbsum/5gme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gme ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gme OCA], [http://pdbe.org/5gme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gme RCSB], [http://www.ebi.ac.uk/pdbsum/5gme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gme ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DMD_SULSO DMD_SULSO]] Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.<ref>PMID:23378249</ref>
[https://www.uniprot.org/uniprot/DMD_SACS2 DMD_SACS2] Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.<ref>PMID:23378249</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Diphosphomevalonate decarboxylase]]
[[Category: Large Structures]]
[[Category: Hattori, A]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Hemmi, H]]
[[Category: Hattori A]]
[[Category: Unno, H]]
[[Category: Hemmi H]]
[[Category: Adp]]
[[Category: Unno H]]
[[Category: Lyase]]
[[Category: Sulfolobus solfataricus]]

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