7xgi: Difference between revisions
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==COMT SAH Mg opicapone complex== | |||
<StructureSection load='7xgi' size='340' side='right'caption='[[7xgi]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XGI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DNI:5-[3-[2,5-bis(chloranyl)-4,6-dimethyl-1-oxidanidyl-pyridin-1-ium-3-yl]-1,2,4-oxadiazol-5-yl]-3-nitro-benzene-1,2-diol'>DNI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xgi OCA], [https://pdbe.org/7xgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xgi RCSB], [https://www.ebi.ac.uk/pdbsum/7xgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xgi ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Kuwada-Kusunose | == Function == | ||
[[Category: Takebe | [https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Iijima H]] | |||
[[Category: Kuwada-Kusunose T]] | |||
[[Category: Suzuki M]] | |||
[[Category: Takebe K]] | |||
[[Category: Uzawa N]] | |||
Latest revision as of 14:09, 2 August 2023
COMT SAH Mg opicapone complexCOMT SAH Mg opicapone complex
Structural highlights
FunctionCOMT_RAT Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. |
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