7vrk: Difference between revisions

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'''Unreleased structure'''


The entry 7vrk is ON HOLD
==crystal structure of BRD2-BD1 in complex with purine derivative==
 
<StructureSection load='7vrk' size='340' side='right'caption='[[7vrk]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
Authors: Padmanabhan, B., Arole, A., Deshmukh, P., Ashok, S., Mathur, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7vrk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VRK FirstGlance]. <br>
Description: crystal structure of BRD2-BD1 in complex with purine derivative
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TEP:THEOPHYLLINE'>TEP</scene></td></tr>
[[Category: Mathur, S]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vrk OCA], [https://pdbe.org/7vrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vrk RCSB], [https://www.ebi.ac.uk/pdbsum/7vrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vrk ProSAT]</span></td></tr>
[[Category: Padmanabhan, B]]
</table>
[[Category: Ashok, S]]
== Function ==
[[Category: Deshmukh, P]]
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
[[Category: Arole, A]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arole A]]
[[Category: Ashok S]]
[[Category: Deshmukh P]]
[[Category: Mathur S]]
[[Category: Padmanabhan B]]

Latest revision as of 14:08, 2 August 2023

crystal structure of BRD2-BD1 in complex with purine derivativecrystal structure of BRD2-BD1 in complex with purine derivative

Structural highlights

7vrk is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.48Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BRD2_HUMAN May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.[1]

References

  1. ↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

7vrk, resolution 2.48Å

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