359d: Difference between revisions

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-{{Seed}}
-[[Image:359d.png|left|200px]]
-<!--
+==INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)==
-The line below this paragraph, containing "STRUCTURE_359d", creates the "Structure Box" on the page.
+<StructureSection load='359d' size='340' side='right'caption='[[359d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[359d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=359D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=359D FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
-{{STRUCTURE_359d|  PDB=359d  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=359d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=359d OCA], [https://pdbe.org/359d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=359d RCSB], [https://www.ebi.ac.uk/pdbsum/359d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=359d ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Terbium(III) [Tb(III)] was shown to inhibit the hammerhead ribozyme by competing with a single magnesium(II) ion. X-ray crystallography revealed that the Tb(III) ion binds to a site adjacent to an essential guanosine in the catalytic core of the ribozyme, approximately 10 angstroms from the cleavage site. Synthetic modifications near this binding site yielded an RNA substrate that was resistant to Tb(III) binding and capable of being cleaved, even in the presence of up to 20 micromolar Tb(III). It is suggested that the magnesium(II) ion thought to bind at this site may act as a switch, affecting the conformational changes required to achieve the transition state.
-===INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III)===
+Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb.,Feig AL, Scott WG, Uhlenbeck OC Science. 1998 Jan 2;279(5347):81-4. PMID:9417029<ref>PMID:9417029</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 359d" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_9417029}}, adds the Publication Abstract to the page
+*[[Ribozyme 3D structures|Ribozyme 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 9417029 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_9417029}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=359D OCA].
+[[Category: Feig AL]]
+[[Category: Scott WG]]
-==Reference==
+[[Category: Uhlenbeck OC]]
-Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb., Feig AL, Scott WG, Uhlenbeck OC, Science. 1998 Jan 2;279(5347):81-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9417029 9417029]
-[[Category: Feig, A L.]]
-[[Category: Scott, W G.]]
-[[Category: Uhlenbeck, O C.]]
-[[Category: Catalytic rna]]
-[[Category: Loop]]
-[[Category: Rna hammerhead ribozyme]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:24:29 2008''