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[[Image:1avc.png|left|200px]]


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==BOVINE ANNEXIN VI (CALCIUM-BOUND)==
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<StructureSection load='1avc' size='340' side='right'caption='[[1avc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1avc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AVC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_1avc|  PDB=1avc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1avc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1avc OCA], [https://pdbe.org/1avc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1avc RCSB], [https://www.ebi.ac.uk/pdbsum/1avc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1avc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANXA6_BOVIN ANXA6_BOVIN] May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/1avc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1avc ConSurf].
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== Publication Abstract from PubMed ==
The crystal structure of a calcium-bound form of bovine annexin VI has been determined with X-ray diffraction data to 2.9 A by molecular replacement. Six Ca2+ ions were found, five in AB loops, one in a DE loop. Two loops (II-AB, which binds calcium, and V-AB, which does not) have conformations that differ significantly from those in calcium-free, human recombinant annexin VI. There are only small differences between the calci- and the apo-annexin VI in the rest of the molecule. Calcium by itself does not promote a major conformational change.


===BOVINE ANNEXIN VI (CALCIUM-BOUND)===
Crystal structure of bovine annexin VI in a calcium-bound state.,Avila-Sakar AJ, Creutz CE, Kretsinger RH Biochim Biophys Acta. 1998 Sep 8;1387(1-2):103-16. PMID:9748523<ref>PMID:9748523</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1avc" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_9748523}}, adds the Publication Abstract to the page
*[[Annexin 3D structures|Annexin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 9748523 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_9748523}}
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</StructureSection>
==About this Structure==
1AVC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AVC OCA].
 
==Reference==
<ref group="xtra">PMID:9748523</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Avila-Sakar, A J.]]
[[Category: Large Structures]]
[[Category: Creutz, C E.]]
[[Category: Avila-Sakar AJ]]
[[Category: Kretsinger, R H.]]
[[Category: Creutz CE]]
[[Category: Annexin]]
[[Category: Kretsinger RH]]
[[Category: Calcium-binding]]
[[Category: Calcium/phospholipid-binding protein]]
[[Category: Membrane-binding]]
 
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