1ahw: Difference between revisions

No edit summary
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)==
==A COMPLEX OF EXTRACELLULAR DOMAIN OF TISSUE FACTOR WITH AN INHIBITORY FAB (5G9)==
<StructureSection load='1ahw' size='340' side='right' caption='[[1ahw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1ahw' size='340' side='right'caption='[[1ahw]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ahw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AHW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ahw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AHW FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ahw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahw OCA], [http://pdbe.org/1ahw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ahw RCSB], [http://www.ebi.ac.uk/pdbsum/1ahw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahw ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ahw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ahw OCA], [https://pdbe.org/1ahw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ahw RCSB], [https://www.ebi.ac.uk/pdbsum/1ahw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ahw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref> 
[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahw_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ahw_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 29: Line 30:


==See Also==
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Tissue factor|Tissue factor]]
*[[Tissue factor|Tissue factor]]
*[[3D structures of antibody|3D structures of antibody]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Edgington, T S]]
[[Category: Edgington TS]]
[[Category: Huang, M]]
[[Category: Huang M]]
[[Category: Ruf, W]]
[[Category: Ruf W]]
[[Category: Stefanko, R S]]
[[Category: Stefanko RS]]
[[Category: Stone, M J]]
[[Category: Stone MJ]]
[[Category: Stura, E A]]
[[Category: Stura EA]]
[[Category: Syed, R]]
[[Category: Syed R]]
[[Category: Wilson, I A]]
[[Category: Wilson IA]]
[[Category: Antibody]]
[[Category: Blood coagulation]]
[[Category: Complex]]
[[Category: Fab]]
[[Category: Tissue factor]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA