1a4s: Difference between revisions

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-[[Image:1a4s.png|left|200px]]
-{{STRUCTURE_1a4s|  PDB=1a4s  |  SCENE=  }}
+==BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER==
+<StructureSection load='1a4s' size='340' side='right'caption='[[1a4s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1a4s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gadus_morhua_callarias Gadus morhua callarias]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A4S FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4s OCA], [https://pdbe.org/1a4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a4s RCSB], [https://www.ebi.ac.uk/pdbsum/1a4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a4s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AL9A1_GADMC AL9A1_GADMC]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/1a4s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a4s ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The three-dimensional structure of betaine aldehyde dehydrogenase, the most abundant aldehyde dehydrogenase (ALDH) of cod liver, has been determined at 2.1 A resolution by the X-ray crystallographic method of molecular replacement. This enzyme represents a novel structure of the highly multiple ALDH, with at least 12 distinct classes in humans. This betaine ALDH of class 9 is different from the two recently determined ALDH structures (classes 2 and 3). Like these, the betaine ALDH structure has three domains, one coenzyme binding domain, one catalytic domain, and one oligomerization domain. Crystals grown in the presence or absence of NAD+ have very similar structures and no significant conformational change occurs upon coenzyme binding. This is probably due to the tight interactions between domains within the subunit and between subunits in the tetramer. The oligomerization domains link the catalytic domains together into two 20-stranded pleated sheet structures. The overall structure is similar to that of the tetrameric bovine class 2 and dimeric rat class 3 ALDH, but the coenzyme binding with the nicotinamide in anti conformation, resembles that of class 2 rather than of class 3.
-===BETAINE ALDEHYDE DEHYDROGENASE FROM COD LIVER===
+Structure of betaine aldehyde dehydrogenase at 2.1 A resolution.,Johansson K, El-Ahmad M, Ramaswamy S, Hjelmqvist L, Jornvall H, Eklund H Protein Sci. 1998 Oct;7(10):2106-17. PMID:9792097<ref>PMID:9792097</ref>
-{{ABSTRACT_PUBMED_9792097}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1a4s" style="background-color:#fffaf0;"></div>
-[[1a4s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gadus_morhua_callarias Gadus morhua callarias]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4S OCA].
 ==See Also==
-*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
+*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:009792097</ref><references group="xtra"/>
+__TOC__
-[[Category: Betaine-aldehyde dehydrogenase]]
+</StructureSection>
 [[Category: Gadus morhua callarias]]
-[[Category: Ahmad, M El.]]
+[[Category: Large Structures]]
-[[Category: Eklund, H.]]
+[[Category: Eklund H]]
-[[Category: Hjelmqvist, L.]]
+[[Category: El Ahmad M]]
-[[Category: Johansson, K.]]
+[[Category: Hjelmqvist L]]
-[[Category: Jornvall, H.]]
+[[Category: Johansson K]]
-[[Category: Ramaswamy, S.]]
+[[Category: Jornvall H]]
-[[Category: Aldehyde oxidation]]
+[[Category: Ramaswamy S]]
-[[Category: Oxidoreductase]]