5fyy: Difference between revisions
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==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 3-pyridin-3-ylaniline (N05798a) (ligand modelled based on PANDDA event map)== | ==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment 3-pyridin-3-ylaniline (N05798a) (ligand modelled based on PANDDA event map)== | ||
<StructureSection load='5fyy' size='340' side='right' caption='[[5fyy]], [[Resolution|resolution]] 2.18Å' scene=''> | <StructureSection load='5fyy' size='340' side='right'caption='[[5fyy]], [[Resolution|resolution]] 2.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5fyy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYY OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5fyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FYY FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=N6Y:3-(PYRIDIN-3-YL)ANILINE'>N6Y</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=N6Y:3-(PYRIDIN-3-YL)ANILINE'>N6Y</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyy OCA], [https://pdbe.org/5fyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fyy RCSB], [https://www.ebi.ac.uk/pdbsum/5fyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fyy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | ||
==See Also== | |||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |||
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Arrowsmith | [[Category: Homo sapiens]] | ||
[[Category: Bountra | [[Category: Large Structures]] | ||
[[Category: Brennan | [[Category: Arrowsmith CH]] | ||
[[Category: Burgess-Brown | [[Category: Bountra C]] | ||
[[Category: Brennan PE]] | |||
[[Category: Edwards | [[Category: Burgess-Brown NA]] | ||
[[Category: Gileadi | [[Category: Edwards AM]] | ||
[[Category: Johansson | [[Category: Gileadi C]] | ||
[[Category: Krojer | [[Category: Johansson C]] | ||
[[Category: Kupinska | [[Category: Krojer T]] | ||
[[Category: Nowak | [[Category: Kupinska K]] | ||
[[Category: Oppermann | [[Category: Nowak R]] | ||
[[Category: Pearce | [[Category: Oppermann U]] | ||
[[Category: Strain-Damerell | [[Category: Pearce N]] | ||
[[Category: Szykowska | [[Category: Strain-Damerell C]] | ||
[[Category: | [[Category: Szykowska A]] | ||
[[Category: Von Delft F]] | |||