5fv7: Difference between revisions

<table><tr><td colspan='2'>[[5fv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FV7 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=R3Z:1-[(2S)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL]-3-HYDROXYTHIENO[3,2-D]PYRIMIDINE-2,4(1H,3H)-DIONE'>R3Z</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fv7 OCA], [https://pdbe.org/5fv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fv7 RCSB], [https://www.ebi.ac.uk/pdbsum/5fv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fv7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FEN1_HUMAN FEN1_HUMAN] Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.<ref>PMID:7961795</ref> <ref>PMID:8621570</ref> <ref>PMID:10744741</ref> <ref>PMID:11986308</ref> <ref>PMID:18443037</ref> <ref>PMID:20729856</ref>  

[[Category: Abbott WM]]

[[Category: Debreczeni JE]]

[[Category: Durant ST]]

[[Category: Exell JC]]

[[Category: Finger LD]]

[[Category: Grasby JA]]

[[Category: Jones CD]]

[[Category: McWhirter C]]

[[Category: Molina DM]]

[[Category: Nissink JWM]]

[[Category: Shaw SK]]

[[Category: Sioberg CWL]]

[[Category: Thompson MJ]]

[[Category: Ward TA]]