5fr6: Difference between revisions

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<StructureSection load='5fr6' size='340' side='right'caption='[[5fr6]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
<StructureSection load='5fr6' size='340' side='right'caption='[[5fr6]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FR6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FR6 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr6 OCA], [http://pdbe.org/5fr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fr6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr6 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr6 OCA], [https://pdbe.org/5fr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fr6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BMI1_HUMAN BMI1_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.<ref>PMID:16359901</ref> <ref>PMID:16882984</ref> <ref>PMID:16714294</ref>
[https://www.uniprot.org/uniprot/BMI1_HUMAN BMI1_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.<ref>PMID:16359901</ref> <ref>PMID:16882984</ref> <ref>PMID:16714294</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Polycomb|Polycomb]]
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cho, H J]]
[[Category: Cho HJ]]
[[Category: Cierpicki, T]]
[[Category: Cierpicki T]]
[[Category: Gray, F]]
[[Category: Gray F]]
[[Category: Bmi1]]
[[Category: Phc2]]
[[Category: Polycomb]]
[[Category: Transcription]]

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