3etx: Difference between revisions

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-{{Seed}}
-[[Image:3etx.png|left|200px]]
-<!--
+==Crystal structure of bacterial adhesin FadA L14A mutant==
-The line below this paragraph, containing "STRUCTURE_3etx", creates the "Structure Box" on the page.
+<StructureSection load='3etx' size='340' side='right'caption='[[3etx]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3etx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum Fusobacterium nucleatum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bc6 2bc6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ETX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3etx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3etx OCA], [https://pdbe.org/3etx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3etx RCSB], [https://www.ebi.ac.uk/pdbsum/3etx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3etx ProSAT]</span></td></tr>
-{{STRUCTURE_3etx|  PDB=3etx  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5I6B0_FUSNU Q5I6B0_FUSNU]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Many bacterial appendages have filamentous structures, often composed of repeating monomers assembled in a head-to-tail manner. The mechanisms of such linkages vary. We report here a novel protein oligomerization motif identified in the FadA adhesin from the Gram-negative bacterium Fusobacterium nucleatum. The 2.0 A crystal structure of the secreted form of FadA (mFadA) reveals two antiparallel -helices connected by an intervening eight-residue hairpin loop. Leucine-leucine contacts play a prominent dual intra- and inter-molecular role in the structure and function of FadA. First, they comprise the main association between the two helical arms of the monomer; second, they mediate the head-to-tail association of monomers to form the elongated polymers. This leucine-mediated filamentous assembly of FadA molecules constitutes a novel structural motif termed the "leucine chain". The essential role of these residues in FadA is corroborated by mutagenesis of selected leucine residues, which leads to the abrogation of oligomerization, filament formation, and binding to host cells.
-===Crystal structure of bacterial adhesin FadA L14A mutant===
+Crystal structure of FadA adhesin from fusobacterium nucleatum reveals a novel oligomerization motif: The leucine chain.,Nithianantham S, Xu M, Yamada M, Ikegami A, Shoham M, Han YW J Biol Chem. 2008 Nov 7. PMID:18996848<ref>PMID:18996848</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3etx" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18996848}}, adds the Publication Abstract to the page
+*[[Adhesin 3D structures|Adhesin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18996848 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18996848}}
+__TOC__
+</StructureSection>
-==About this Structure==
-ETX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Fusobacterium_nucleatum Fusobacterium nucleatum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2bc6 2bc6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ETX OCA].
-==Reference==
-Crystal structure of FadA adhesin from fusobacterium nucleatum reveals a novel oligomerization motif: The leucine chain., Nithianantham S, Xu M, Yamada M, Ikegami A, Shoham M, Han YW, J Biol Chem. 2008 Nov 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18996848 18996848]
 [[Category: Fusobacterium nucleatum]]
-[[Category: Han, Y W.]]
+[[Category: Large Structures]]
-[[Category: Nithianantham, S.]]
+[[Category: Han YW]]
-[[Category: Shoham, M.]]
+[[Category: Nithianantham S]]
-[[Category: Wu, N.]]
+[[Category: Shoham M]]
-[[Category: Xu, M.]]
+[[Category: Wu N]]
-[[Category: Antiparallel helix-loop-helix]]
+[[Category: Xu M]]
-[[Category: Cell adhesin]]
-[[Category: Cell adhesion]]
-[[Category: Fada l14a mutant]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:39:59 2008''