7yl2: Difference between revisions
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==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004== | |||
<StructureSection load='7yl2' size='340' side='right'caption='[[7yl2]], [[Resolution|resolution]] 1.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yl2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YL2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JCO:N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide'>JCO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yl2 OCA], [https://pdbe.org/7yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/7yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yl2 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Li | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
[[Category: | == References == | ||
[[Category: Xu | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen Z]] | |||
[[Category: Dong R]] | |||
[[Category: Huang Y]] | |||
[[Category: Li J]] | |||
[[Category: Wei A]] | |||
[[Category: Wu X]] | |||
[[Category: Xu H]] | |||
[[Category: Xu Y]] | |||
[[Category: Zhang C]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 15:34, 26 July 2023
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). References
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