Nuclear transcription factor Y: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1n1j' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Nuclear transcription factor Y''' (NFY) binds to a CCAAT sequence... |
Michal Harel (talk | contribs) No edit summary |
||
| (15 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='' size='350' side='right' caption='Human nuclear transcription factor Y subunit α (cyan), subunit β (green) and subunit γ (pink) complex with HSP70 promoter DNA fragment (PDB code [[4awl]])' scene='72/725371/Cv/1'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''Nuclear transcription factor Y''' (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence<ref>PMID:9612081</ref>. See details in [[NF-Y Transcription Factor]]. | '''Nuclear transcription factor Y''' (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence<ref>PMID:9612081</ref>. See details in [[NF-Y Transcription Factor]]. | ||
== Relevance == | == Relevance == | ||
NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer<ref>PMID:9095180</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
<scene name='72/725371/Cv/5'>Human nuclear transcription factor Y subunit α, subunit β, subunit γ with HSP70 promoter fragment</scene> (PDB code [[4awl]]). The <scene name='72/725371/Cv/6'>interaction of NFY with the promoter CCAAT sequence, involves an insertion of an NFY helix into the minor groove of the DNA</scene><ref>PMID:23332751</ref>. | |||
</StructureSection> | </StructureSection> | ||
| Line 21: | Line 16: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1n1j]], [[4csr]] – hNFY β+γ subunits - human<br /> | [[1n1j]], [[4csr]], [[7ah8]] – hNFY β+γ subunits - human<br /> | ||
[[6qmp]], [[6qmq]], [[6qms]] – hNFY α peptide+β+γ subunits <br /> | |||
[[4awl]] – hNFY α+β+γ subunits + promoter DNA<br /> | [[4awl]] – hNFY α+β+γ subunits + promoter DNA<br /> | ||
[[5g49]] – AtNFY β6+γ3 subunits – ''Arabidopsis thaliana''<br /> | |||
[[6r0m]], [[6r0n]] – AtNFY b2+c3 subunits histone-fold domain<br /> | |||
[[6r2v]] – AtNFY a6+b2+c3 subunits + DNA<br /> | |||
[[7cvq]] – AtNFY b2+c3 subunits + DNA<br /> | |||
[[7cvo]] – AtNFY b2+b3+c3+c4 subunits + DNA<br /> | |||
[[7c9p]] – rNFY b11+c2 subunits – rice<br /> | |||
[[7c9o]] – rNFY b11+c2 subunits + zinc finger protein HD1 + DNA<br /> | |||
[[6r0m]], [[6r0n]] – AtNFY b2+c3 subunits histone-fold domain<br /> | |||
[[6r0l]] – rNFY c7 subunit + OsGhd8 <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||