5foo: Difference between revisions

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-'''Unreleased structure'''
-The entry 5foo is ON HOLD
+==6-phospho-beta-glucosidase==
+<StructureSection load='5foo' size='340' side='right'caption='[[5foo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5foo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_M1_GAS Streptococcus pyogenes M1 GAS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FOO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JAZ:6-PHOSPHOCYCLOPHELLITOL'>JAZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5foo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5foo OCA], [https://pdbe.org/5foo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5foo RCSB], [https://www.ebi.ac.uk/pdbsum/5foo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5foo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q99YP9_STRP1 Q99YP9_STRP1]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Covalent, mechanism-based inhibitors of glycosidases are valuable probe molecules for visualizing enzyme activities in complex systems. We, here, describe the chemoenzymatic synthesis of 6-phospho-cyclophellitol and evaluate its behaviour as a mechanism-based inactivator of the Streptococcus pyogenes 6-phospho-beta-glucosidase from CAZy family GH1. We further present the three-dimensional structure of the inactivated enzyme, which reveals the constellation of active site residues responsible for the enzyme's specificity and confirms the covalent nature of the inactivation.
-Authors: Jin, Y., Kwan, D.H., Withers, S.G., Davies, G.J.
+Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-beta-glucosidases.,Kwan DH, Jin Y, Jiang J, Chen HM, Kotzler MP, Overkleeft HS, Davies GJ, Withers SG FEBS Lett. 2016 Feb;590(4):461-8. doi: 10.1002/1873-3468.12059. Epub 2016 Feb 14. PMID:26790390<ref>PMID:26790390</ref>
-Description: 6-phospho-beta-glucosidase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Davies, G.J]]
+<div class="pdbe-citations 5foo" style="background-color:#fffaf0;"></div>
-[[Category: Withers, S.G]]
-[[Category: Kwan, D.H]]
+==See Also==
-[[Category: Jin, Y]]
+*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Streptococcus pyogenes M1 GAS]]
+[[Category: Davies GJ]]
+[[Category: Jin Y]]
+[[Category: Kwan DH]]
+[[Category: Withers SG]]