5flv: Difference between revisions

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OCA

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 ==Crystal structure of NKX2-5 and TBX5 bound to the Nppa promoter region==
-<StructureSection load='5flv' size='340' side='right' caption='[[5flv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='5flv' size='340' side='right'caption='[[5flv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5flv]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FLV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5flv]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FLV FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.005&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fm6|5fm6]], [[5fm7|5fm7]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5flv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flv OCA], [http://pdbe.org/5flv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5flv RCSB], [http://www.ebi.ac.uk/pdbsum/5flv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5flv ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5flv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flv OCA], [https://pdbe.org/5flv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5flv RCSB], [https://www.ebi.ac.uk/pdbsum/5flv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5flv ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NKX25_MOUSE NKX25_MOUSE] Transcription factor required for the development of the heart and the spleen (PubMed:9584153, PubMed:19483677, PubMed:22560297). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed:9584153). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302). Binds to the core DNA motif of NPPA promoter (PubMed:19483677). Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity).[UniProtKB:P52952]<ref>PMID:12023302</ref> <ref>PMID:19483677</ref> <ref>PMID:22560297</ref> <ref>PMID:9584153</ref> [https://www.uniprot.org/uniprot/TBX5_MOUSE TBX5_MOUSE] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter.[UniProtKB:Q99593]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 ==See Also==
+*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
 *[[T-box proteins|T-box proteins]]
 == References ==
@@ Line 24: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Glatt, S]]
+[[Category: Large Structures]]
-[[Category: Mueller, C W]]
+[[Category: Mus musculus]]
-[[Category: Stirnimann, C U]]
+[[Category: Glatt S]]
-[[Category: Transcription]]
+[[Category: Mueller CW]]
+[[Category: Stirnimann CU]]