5fku: Difference between revisions

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 ==cryo-EM structure of the E. coli replicative DNA polymerase complex in DNA free state (DNA polymerase III alpha, beta, epsilon, tau complex)==
-<StructureSection load='5fku' size='340' side='right' caption='[[5fku]], [[Resolution|resolution]] 8.34&Aring;' scene=''>
+<SX load='5fku' size='340' side='right' viewer='molstar' caption='[[5fku]], [[Resolution|resolution]] 8.34&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5fku]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FKU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5fku]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FKU FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fkv|5fkv]], [[5fkw|5fkw]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.34&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fku OCA], [https://pdbe.org/5fku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fku RCSB], [https://www.ebi.ac.uk/pdbsum/5fku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fku ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fku OCA], [http://pdbe.org/5fku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fku RCSB], [http://www.ebi.ac.uk/pdbsum/5fku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fku ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DPO3X_ECOLI DPO3X_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.  Isoform tau: serves as a scaffold to help in the dimerization of the core complex.  Isoform gamma: seems to interact with the delta subunit. to transfer the beta subunit on the DNA. [[http://www.uniprot.org/uniprot/DPO3A_ECOLI DPO3A_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. [[http://www.uniprot.org/uniprot/DPO3E_ECOLI DPO3E_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. [[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
+[https://www.uniprot.org/uniprot/DPO3A_ECOLI DPO3A_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 5fku" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: DNA-directed DNA polymerase]]
+[[Category: Escherichia coli K-12]]
-[[Category: Conrad, J]]
+[[Category: Large Structures]]
-[[Category: Fernandez-Leiro, R]]
+[[Category: Conrad J]]
-[[Category: Lamers, M H]]
+[[Category: Fernandez-Leiro R]]
-[[Category: Scheres, S H.W]]
+[[Category: Lamers MH]]
-[[Category: Dna polymerase iii alpha]]
+[[Category: Scheres SHW]]
-[[Category: Dna polymerase iii beta]]
-[[Category: Dna polymerase iii epsilon]]
-[[Category: Dna polymerase iii tau]]
-[[Category: Dna replication]]
-[[Category: Transferase]]