5fjo: Difference between revisions

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-'''Unreleased structure'''
-The entry 5fjo is ON HOLD
+==N-acyl amino acid racemase from Amycolatopsis sp. Ts-1-60: G291D- F323Y mutant in complex with N-acetyl naphthylalanine==
+<StructureSection load='5fjo' size='340' side='right'caption='[[5fjo]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
-Authors: Sanchez-Carron, G., Campopiano, D., Grogan, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FJO FirstGlance]. <br>
-Description: N-acyl amino acid racemase from Amycolatopsis sp. Ts-1-60: G291D-F323Y mutant in complex with N-acetyl naphthylalanine
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NPQ:N-ACETYL+NAPHTHYLALANINE'>NPQ</scene></td></tr>
-[[Category: Grogan, G]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjo OCA], [https://pdbe.org/5fjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fjo RCSB], [https://www.ebi.ac.uk/pdbsum/5fjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjo ProSAT]</span></td></tr>
-[[Category: Sanchez-Carron, G]]
+</table>
-[[Category: Campopiano, D]]
+== Function ==
+[https://www.uniprot.org/uniprot/NSAR_AMYSP NSAR_AMYSP] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-propionyl-D/L-methionine, N-butyryl-D/L-methionine and N-chloroacetyl-L-valine (PubMed:7766084, PubMed:10194342, PubMed:14705949, PubMed:23130969). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:14705949, PubMed:24955846). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).<ref>PMID:10194342</ref> <ref>PMID:14705949</ref> <ref>PMID:23130969</ref> <ref>PMID:24955846</ref> <ref>PMID:7766084</ref> <ref>PMID:16740275</ref> <ref>PMID:24955846</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Amycolatopsis sp]]
+[[Category: Large Structures]]
+[[Category: Campopiano D]]
+[[Category: Grogan G]]
+[[Category: Sanchez-Carron G]]