5fbx: Difference between revisions
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New page: '''Unreleased structure''' The entry 5fbx is ON HOLD Authors: Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edward... |
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==Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor== | |||
<StructureSection load='5fbx' size='340' side='right'caption='[[5fbx]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5fbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W4:(3~{S})-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-2-METHYL-3-PHENYL-3~{H}-ISOINDOL-1-ONE'>5W4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbx OCA], [https://pdbe.org/5fbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbx RCSB], [https://www.ebi.ac.uk/pdbsum/5fbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbx ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Clark PGK]] | ||
[[Category: | [[Category: Dixon D]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Fedorov O]] | ||
[[Category: Tallant | [[Category: Knapp S]] | ||
[[Category: | [[Category: Muller S]] | ||
[[Category: Nowak R]] | |||
[[Category: Siejka P]] | |||
[[Category: Srikannathasan V]] | |||
[[Category: Tallant C]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 09:45, 19 July 2023
Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitorCrystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). See AlsoReferences
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