5f61: Difference between revisions

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 ==Crystal structure of the first bromodomain of human BRD4 in complex with MA4-022-1==
-<StructureSection load='5f61' size='340' side='right' caption='[[5f61]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
+<StructureSection load='5f61' size='340' side='right'caption='[[5f61]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5f61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F61 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5f61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F61 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5W0:~{N}-[3-[[2-[[3-FLUORANYL-4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]-5-METHYL-PYRIMIDIN-4-YL]AMINO]PHENYL]-2-METHYL-PROPANE-2-SULFONAMIDE'>5W0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f5z|5f5z]], [[5f60|5f60]], [[5f62|5f62]], [[5f63|5f63]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W0:~{N}-[3-[[2-[[3-FLUORANYL-4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO]-5-METHYL-PYRIMIDIN-4-YL]AMINO]PHENYL]-2-METHYL-PROPANE-2-SULFONAMIDE'>5W0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f61 OCA], [http://pdbe.org/5f61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f61 RCSB], [http://www.ebi.ac.uk/pdbsum/5f61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f61 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f61 OCA], [https://pdbe.org/5f61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f61 RCSB], [https://www.ebi.ac.uk/pdbsum/5f61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f61 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 </div>
 <div class="pdbe-citations 5f61" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ember, S W]]
+[[Category: Homo sapiens]]
-[[Category: Schonbrunn, E]]
+[[Category: Large Structures]]
-[[Category: Zhu, J Y]]
+[[Category: Ember SW]]
-[[Category: Cap]]
+[[Category: Schonbrunn E]]
-[[Category: Cell cycle]]
+[[Category: Zhu J-Y]]
-[[Category: Hunk1]]
-[[Category: Inhibitor]]
-[[Category: Mcap]]
-[[Category: Mitotic chromosome associated protein]]
-[[Category: Protein binding-inhibitor complex]]
-[[Category: Romodomain]]
-[[Category: Transcription-transcription inhibitor complex]]