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==HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir==
==HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir==
<StructureSection load='3lon' size='340' side='right' caption='[[3lon]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3lon' size='340' side='right'caption='[[3lon]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lon]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LON FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lon]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LON FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NNA:(1R,2S,5S)-3-[N-({1-[(TERT-BUTYLSULFONYL)METHYL]CYCLOHEXYL}CARBAMOYL)-3-METHYL-L-VALYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]PENTYL}-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE'>NNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31646 Hepatitis C virus subtype 1a])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=NNA:(1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide'>NNA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lon OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lon RCSB], [http://www.ebi.ac.uk/pdbsum/3lon PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lon OCA], [https://pdbe.org/3lon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lon RCSB], [https://www.ebi.ac.uk/pdbsum/3lon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lon ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ELS8_9HEPC Q9ELS8_9HEPC]
==See Also==
*[[Virus protease 3D structures|Virus protease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Hepatitis C virus genotype 1a]]
[[Category: Prongay, A J]]
[[Category: Large Structures]]
[[Category: Atp-binding]]
[[Category: Prongay AJ]]
[[Category: Capsid protein]]
[[Category: Envelope protein]]
[[Category: Helicase]]
[[Category: Hepatitis c virus]]
[[Category: Host membrane]]
[[Category: Hydrolase]]
[[Category: Macrocyclic ketoamide inhibitor]]
[[Category: Membrane]]
[[Category: Ns3 protease domain]]
[[Category: Nucleotide-binding]]
[[Category: Rna replication]]
[[Category: Serine protease]]
[[Category: Transmembrane]]
[[Category: Viral protein]]
[[Category: Viral protein-inhibitor complex]]
[[Category: Virion]]

Latest revision as of 09:36, 19 July 2023

HCV NS3-4a protease domain with ketoamide inhibitor narlaprevirHCV NS3-4a protease domain with ketoamide inhibitor narlaprevir

Structural highlights

3lon is a 4 chain structure with sequence from Hepatitis C virus genotype 1a. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9ELS8_9HEPC

See Also

3lon, resolution 2.20Å

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