8set: Difference between revisions
New page: '''Unreleased structure''' The entry 8set is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Cryo-EM Structure of RyR1 + cAMP== | |||
<StructureSection load='8set' size='340' side='right'caption='[[8set]], [[Resolution|resolution]] 3.42Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8set]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SET FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8set FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8set OCA], [https://pdbe.org/8set PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8set RCSB], [https://www.ebi.ac.uk/pdbsum/8set PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8set ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Berezuk AM]] | |||
[[Category: Cholak S]] | |||
[[Category: Haji-Ghassemi O]] | |||
[[Category: Saville JW]] | |||
[[Category: Subramaniam S]] | |||
[[Category: Tuttle KS]] | |||
[[Category: Van Petegem F]] | |||
[[Category: Zhu X]] | |||