NF-kB: Difference between revisions

Latest revision as of 10:16, 16 July 2023

Function

NF-kB or Nuclear Factor NF-kappa is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA^[1]. I-κ-B-α is an inhibitor of NF-kB.

There are 5 proteins in the NF-kB family:

NF-kB1 (synthesized as p105 and processed to p50)
NF-kB2 (synthesized as p100 and processed to p52)
RelA (or p65 subunit of NF-kB)
RelB
cRel.

Relevance

NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents^[2]. NF-kB is a critical link between inflammation and cancer^[3].

3D structures of NF-kappaB3D structures of NF-kappaB

Updated on 16-July-2023

ReferencesReferences

↑ Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004 Sep 15;18(18):2195-224. PMID:15371334 doi:http://dx.doi.org/10.1101/gad.1228704
↑ Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun;45(6):355-61. PMID:16673382 doi:http://dx.doi.org/10.1002/mc.20217
↑ Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi:, 10.1101/cshperspect.a000141. PMID:20066113 doi:http://dx.doi.org/10.1101/cshperspect.a000141

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004 Sep 15;18(18):2195-224. PMID:15371334 doi:http://dx.doi.org/10.1101/gad.1228704

[2] Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun;45(6):355-61. PMID:16673382 doi:http://dx.doi.org/10.1002/mc.20217

[3] Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a000141. doi:, 10.1101/cshperspect.a000141. PMID:20066113 doi:http://dx.doi.org/10.1101/cshperspect.a000141

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
 <StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''>
+== Function ==
-'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor.  It is involved in cellular response to stimuli.  NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA.  There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''.  I-κ-B-α is an inhibitor of NF-kB.
+'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor.  It is involved in cellular response to stimuli.  NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>.  I-κ-B-α is an inhibitor of NF-kB.<br />
+There are 5 proteins in the NF-kB family:<br />
+*'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br />
+*'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br />
+*'''RelA''' (or '''p65''' subunit of NF-kB)<br />
+*'''RelB'''<br />
+*'''cRel'''.
+See also [[NF-kB (hebrew)]].
+== Relevance ==
+NF-kB plays a critical role in cancer development and progression and may determine its response to therapy.  NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. NF-kB is a critical link between inflammation and cancer<ref>PMID:20066113</ref>.
+</StructureSection>
 ==3D structures of NF-kappaB==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*RelA (p65)
+**[[1bft]], [[1my5]] – mRelA dimerization domain – mouse <br />
+**[[1my7]] – mRelA dimerization domain (mutant) <br />
+**[[1ram]], [[2ram]] – mRelA residues 19-291 + DNA <br />
+**[[1k3z]], [[1oy3]] – mRelA dimerization domain + I-κ-B-α <br />
-===RelA (p65)===
+*NF-kB1 (p50)
-[[1bft]], [[1my5]] – mRelA dimerization domain – mouse <br />
+**[[1svc]] – hp50 + DNA - human - NMR<br />
-[[1my7]] – mRelA dimerization domain (mutant) <br />
+**[[1nfk]] – mp50 + DNA<br />
-[[1ram]], [[2ram]] – mRelA residues 19-291 + DNA <br />
+**[[1bfs]] – mp50 dimerization domain<br />
-[[1k3z]], [[1oy3]] – mRelA dimerization domain + I-κ-B-α <br />
+**[[1u36]], [[1u3j]], [[1u3y]], [[1u3z]], [[1u41]], [[1u42]] – mp50 dimerization domain (mutant)<br />
-===NF-kB1 (p50)===
+*NF-kB1 (p52)
-[[1svc]] – hp50 + DNA - human - NMR<br />
+**[[7cli]], [[7vup]], [[7vuq]], [[7w7l]] – hp52 + DNA <br />
-[[1nfk]] – mp50 + DNA<br />
-[[1bfs]] – mp50 dimerization domain<br />
-[[1u36]], [[1u3j]], [[1u3y]], [[1u3z]], [[1u41]], [[1u42]] – mp50 dimerization domain (mutant)<br />
-===NF-kB1 (p105)===
+*NF-kB1 (p105)
-[[2dbf]] – hp105 death domain<br />
+**[[2dbf]] – hp105 death domain<br />
-[[1ooa]] – mp105 + RNA<br />
+**[[1ooa]] – mp105 + RNA<br />
-===NF-kB1 + RelA===
+*NF-kB1 + RelA
-[[1nfi]] – hp50 + RelA + I-κ-B-α <br />
+**[[1nfi]] – hp50 + RelA + I-κ-B-α <br />
-[[1ikn]] – mp50 + RelA + I-κ-B-α <br />
+**[[1ikn]] – mp50 + RelA + I-κ-B-α <br />
-[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br />
+**[[1vkx]], [[1le5]], [[1le9]], [[1lei]] – mp50 + RelA + DNA<br />
-[[2i9t]] – mp105 + RelA + DNA<br />
+**[[2i9t]] – mp105 + RelA + DNA<br />
-[[2v2t]] – mp50 + RelB + DNA<br />
+**[[2v2t]] – mp50 + RelB + DNA<br />
-[[2o61]] – hp105 RHR domain + RelA + DNA<br />
+**[[2o61]] – hp105 RHR domain + RelA + DNA<br />
-[[3gut]] – hp105 + RelA + DNA<br />
+**[[3gut]] – hp105 + RelA + DNA<br />
-[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br />
+**[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br />
+}}
+== References ==
+<references/>
 [[Category:Topic Page]]