Neuroligin: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' scene='42/422448/Cv/2' caption='Dimer of two mouse neuroligin-1 cholinesterase-like domains (magenta and cyan) in complex with two neurexin-beta1 LNS6 domains (salmon and yellow) and Ca+2 ions (green) [[3b3q]]'> | ||
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*'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br /> | *'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br /> | ||
*'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br /> | *'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br /> | ||
*'''NLGN-3''' is a synapse organizer which shapes normal function and autism disorder<ref>PMID:17897391</ref>. <br /> | |||
*'''NLGN-4''' is localized to glyceric post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br /> | *'''NLGN-4''' is localized to glyceric post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br /> | ||
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== Structural insights == | == Structural insights == | ||
The <scene name='42/422448/Cv/ | The <scene name='42/422448/Cv/5'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Neuroligin == | == 3D Structures of Neuroligin == | ||
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* Neuroligin | * Neuroligin | ||
**[[5ojk]] - hNLGN-1 cholinesterase domain - human<br /> | |||
**[[3bix]] - rNLGN-1 cholinesterase domain - rat<br /> | |||
**[[8gs4]] - hNLGN-2 – Cryo EM<br /> | |||
**[[3bl8]] - mNLGN-2 cholinesterase domain – mouse<br /> | **[[3bl8]] - mNLGN-2 cholinesterase domain – mouse<br /> | ||
**[[7cee]] - mNLGN-3 cholinesterase domain<br /> | |||
**[[3be8]] - hNLGN-4 cholinesterase domain – human<br /> | **[[3be8]] - hNLGN-4 cholinesterase domain – human<br /> | ||
* Neuroligin+neurexin | * Neuroligin+neurexin | ||
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*NLGN other complexes | *NLGN other complexes | ||
**[[5oj6]] - rNLGN-1 cholinesterase domain + MDGA1<br /> | |||
**[[5v5v]] - rNLGN-2 cholinesterase domain + MDGA1<br /> | **[[5v5v]] - rNLGN-2 cholinesterase domain + MDGA1<br /> | ||
**[[5xeq]] - rNLGN-2 cholinesterase domain (mutant) + MDGA1<br /> | **[[5xeq]] - rNLGN-2 cholinesterase domain (mutant) + MDGA1<br /> | ||
**[[7ceg]] - mNLGN-3 cholinesterase domain + PTP d<br /> | |||
}} | }} | ||