Neuroligin: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Pascale Marchot, Joel L. Sussman

@@ Line 1: / Line 1: @@
-[[Image:3be8a.png|left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]]]]
+<StructureSection load='' size='350' side='right' scene='42/422448/Cv/2' caption='Dimer of two mouse neuroligin-1 cholinesterase-like domains (magenta and cyan) in complex with two neurexin-beta1 LNS6 domains (salmon and yellow) and Ca+2 ions (green) [[3b3q]]'>
-{{STRUCTURE_3b3q|  PDB=3b3q  | SIZE=350| SCENE= |right|CAPTION=Dimer of two mouse neuroligin-1 cholinesterase-like domains (grey and green) in complex with two neurexin-beta1 LNS6 domains (pink and cyan) and Ca+2 ions (green) [[3b3q]] }}
@@ Line 30: / Line 11: @@
 *'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br />
 *'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br />
+*'''NLGN-3''' is a synapse organizer which shapes normal function and autism disorder<ref>PMID:17897391</ref>. <br />
 *'''NLGN-4''' is localized to glyceric  post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br />
@@ Line 35: / Line 17: @@
 Mutations in NLGN 4 are associated with autism and mental retardation<ref>PMID:19726642</ref>.
+== Structural insights ==
+The <scene name='42/422448/Cv/5'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules are shown as red spheres.
+</StructureSection>
 == 3D Structures of Neuroligin ==
@@ Line 42: / Line 27: @@
 * Neuroligin
+**[[5ojk]] -  hNLGN-1 cholinesterase domain - human<br />
+**[[3bix]] -  rNLGN-1 cholinesterase domain - rat<br />
+**[[8gs4]] -  hNLGN-2 – Cryo EM<br />
 **[[3bl8]] -  mNLGN-2 cholinesterase domain – mouse<br />
+**[[7cee]] - mNLGN-3 cholinesterase domain<br />
 **[[3be8]] -  hNLGN-4 cholinesterase domain – human<br />
-**[[3bix]] -  rNLGN-1 cholinesterase domain - rat<br />
 * Neuroligin+neurexin
@@ Line 52: / Line 40: @@
 **[[3biw]] -  rNLGN-1 cholinesterase domain+NRXN-1β LNS domain<br />
 **[[3vkf]] - rNLGN-1 cholinesterase domain + bNRXN-1β LNS domain
+*NLGN other complexes
+**[[5oj6]] -  rNLGN-1 cholinesterase domain + MDGA1<br />
+**[[5v5v]] -  rNLGN-2 cholinesterase domain + MDGA1<br />
+**[[5xeq]] -  rNLGN-2 cholinesterase domain (mutant) + MDGA1<br />
+**[[7ceg]] -  mNLGN-3 cholinesterase domain + PTP d<br />
 }}
 == References ==
 <references/>
 [[Category:Topic Page]]