Neuroglobin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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+<StructureSection load='' size='400' side='right' scene='44/443478/Cv/2' caption='Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]]' pspeed='8'>
-{{STRUCTURE_3gk9|  PDB=3gk9  | SIZE=400| SCENE= |right|CAPTION=Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]] }}
+== Function ==
 '''Neuroglobin''' (NGB) is involved in cellular oxygen homeostasis.  It binds oxygen reversibly.  It increases oxygen availability in the brain.  It is a monomer containing a heme group<ref>PMID:15298922</ref>.
+== Relevance ==
+NGB may influence the course of Alzhheimer's disease<ref>PMID:23648513</ref>.
+== Structural highlights ==
+*<scene name='44/443478/Cv/15'>Heme binding site</scene>. Water molecules are shown as red spheres.
+*<scene name='44/443478/Cv/16'>1st Xe coordination site</scene>.
+*<scene name='44/443478/Cv/17'>2nd Xe coordination site</scene>.
+*<scene name='44/443478/Cv/18'>3rd Xe binding site</scene>.
+*<scene name='44/443478/Cv/19'>4th Xe binding site</scene>.
+</StructureSection>
 == 3D Structures of Neuroglobin ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[3gk9]], [[3gkt]], [[2vry]], [[1q1f]], [[4mu5]], [[4nzi]], [[4o1t]], [[4o4t]] – mNGB (mutant) – mouse<br />
+[[4mpm]] – hNGB - human<br />
-[[3gln]], [[1w92]], [[4o2g]], [[4o35]] – mNGB (mutant) + CO<br />
+[[1oj6]], [[7vqg]] – hNGB (mutant) <br />
-[[4o4z]] – mNGB (mutant) + N2O<br />
+[[5eet]], [[6r1q]] – mNGB – mouse<br />
-[[1oj6]] – hNGB (mutant) - human<br />
+[[3gk9]], [[3gkt]], [[2vry]], [[1q1f]], [[4mu5]], [[4nzi]], [[4o1t]], [[4o4t]], [[5eoh]], [[5eqm]], [[5eu2]], [[5ev5]], [[5eyj]], [[5eys]], [[5f0b]], [[5f2a]], [[5nvi]], [[5nw6]], [[5o17]], [[5o18]], [[5o1k]], [[5o27]], [[6eye]], [[6h5z]], [[6h6c]], [[6h6i]], [[6ra6]], [[7ohd]] – mNGB (mutant) <br />
-[[4mpm]] – hNGB<br />
+[[6i3t]], [[6i40]] – mNGB + CO<br />
+[[3gln]], [[1w92]], [[4o2g]], [[4o35]], [[6h6j]] – mNGB (mutant) + CO<br />
+[[4o4z]] – mNGB (mutant) + N<sub>2</sub>O<br />
+[[5mjc]], [[5mjd]] – mNGB + O<sub>2</sub><br />
 [[4b4y]] – NGB – ''Symsagittifera roscoffensis''<br />
 == References ==
 <references/>
 [[Category:Topic Page]]