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==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49== | ==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49== | ||
<StructureSection load='5epb' size='340' side='right' caption='[[5epb]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5epb' size='340' side='right'caption='[[5epb]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5epb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EPB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [https://pdbe.org/5epb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [https://www.ebi.ac.uk/pdbsum/5epb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
==See Also== | |||
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Caflisch A]] | ||
[[Category: | [[Category: Dong J]] | ||
Latest revision as of 11:13, 12 July 2023
Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49
Structural highlights
FunctionATAD2_HUMAN May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.[1] See AlsoReferences
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