5enb: Difference between revisions
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==Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)== | ==Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with o-Tolylthiourea (SGC - Diamond I04-1 fragment screening)== | ||
<StructureSection load='5enb' size='340' side='right' caption='[[5enb]], [[Resolution|resolution]] 1.73Å' scene=''> | <StructureSection load='5enb' size='340' side='right'caption='[[5enb]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5enb]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5enb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ENB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5Q5:1-(2-METHYLPHENYL)THIOUREA'>5Q5</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5enb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enb OCA], [https://pdbe.org/5enb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5enb RCSB], [https://www.ebi.ac.uk/pdbsum/5enb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5enb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5enb" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5enb" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Bradley | [[Category: Bountra C]] | ||
[[Category: Brennan | [[Category: Bradley A]] | ||
[[Category: Burgess-Brown | [[Category: Brennan P]] | ||
[[Category: Collins | [[Category: Burgess-Brown N]] | ||
[[Category: Cox | [[Category: Collins P]] | ||
[[Category: Cox O]] | |||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Krojer | [[Category: Krojer T]] | ||
[[Category: Szykowska A]] | |||
[[Category: Szykowska | [[Category: Talon R]] | ||
[[Category: Talon | [[Category: Von Delft F]] | ||
[[Category: | |||