1yzm: Difference between revisions
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==Structure of Rabenosyn (458-503), Rab4 binding domain== | ==Structure of Rabenosyn (458-503), Rab4 binding domain== | ||
<StructureSection load='1yzm' size='340' side='right' caption='[[1yzm]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='1yzm' size='340' side='right'caption='[[1yzm]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yzm]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1yzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZM FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yzm OCA], [https://pdbe.org/1yzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yzm RCSB], [https://www.ebi.ac.uk/pdbsum/1yzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yzm ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RBNS5_HUMAN RBNS5_HUMAN] Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).<ref>PMID:11062261</ref> <ref>PMID:11788822</ref> <ref>PMID:15020713</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Eathiraj | [[Category: Large Structures]] | ||
[[Category: Lambright | [[Category: Eathiraj S]] | ||
[[Category: Pan | [[Category: Lambright DG]] | ||
[[Category: Ritacco | [[Category: Pan X]] | ||
[[Category: Ritacco C]] | |||