1yzm: Difference between revisions

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==Structure of Rabenosyn (458-503), Rab4 binding domain==
==Structure of Rabenosyn (458-503), Rab4 binding domain==
<StructureSection load='1yzm' size='340' side='right' caption='[[1yzm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='1yzm' size='340' side='right'caption='[[1yzm]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1yzm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YZM FirstGlance]. <br>
<table><tr><td colspan='2'>[[1yzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yzm OCA], [http://pdbe.org/1yzm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yzm RCSB], [http://www.ebi.ac.uk/pdbsum/1yzm PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yzm OCA], [https://pdbe.org/1yzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yzm RCSB], [https://www.ebi.ac.uk/pdbsum/1yzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yzm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RBNS5_HUMAN RBNS5_HUMAN]] Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).<ref>PMID:11062261</ref> <ref>PMID:11788822</ref> <ref>PMID:15020713</ref>
[https://www.uniprot.org/uniprot/RBNS5_HUMAN RBNS5_HUMAN] Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).<ref>PMID:11062261</ref> <ref>PMID:11788822</ref> <ref>PMID:15020713</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Eathiraj, S]]
[[Category: Large Structures]]
[[Category: Lambright, D G]]
[[Category: Eathiraj S]]
[[Category: Pan, X]]
[[Category: Lambright DG]]
[[Category: Ritacco, C]]
[[Category: Pan X]]
[[Category: Protein transport]]
[[Category: Ritacco C]]
[[Category: Rab effector]]
[[Category: Rab gtpase]]
[[Category: Rabenosyn]]
[[Category: Vesicular trafficking]]

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