NADP-dependent malic enzyme: Difference between revisions

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PDBe, Jaime Prilusky, Michal Harel

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-number of documents: 595
+<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''>
-== Lysozyme ==
+Best example is PDB entry [[3wja]] and is shown in the viewer.<br>
-<StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''>
+==Catalytic Activity ==
-Best example is 1swy<br>
+Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br>
-Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
+Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>.
-== Function ==
-lysozyme activity<br>
-catalytic activity<br>
-hydrolase activity<br>
-hydrolase activity, acting on glycosyl bonds<br>
-carbon-oxygen lyase activity, acting on polysaccharides<br>
-lyase activity<br>
-chitinase activity<br>
-hydrolase activity, hydrolyzing O-glycosyl compounds<br>
-sequence-specific DNA binding<br>
-== Disease ==
-== Relevance ==
-== Structural highlights ==
 == Biological process ==
 Is involved in the following biological processes:<br>
-cell wall macromolecule catabolic process<br>
+malate metabolic process<br>
-peptidoglycan catabolic process<br>
+oxidation-reduction process<br>
-metabolic process<br>
+response to carbohydrate<br>
-defense response to bacterium<br>
+response to hormone<br>
-cytolysis<br>
-viral release from host cell<br>
 carbohydrate metabolic process<br>
-chitin catabolic process<br>
+protein tetramerization<br>
-polysaccharide catabolic process<br>
+regulation of NADP metabolic process<br>
-cytolysis by virus of host cell<br>
+NADP biosynthetic process<br>
-cell wall organization<br>
+small molecule metabolic process<br>
+cellular lipid metabolic process<br>
 == In structures ==
-Lysozyme is found in 595 PDB entries<br>
+NADP-dependent malic enzyme is found in 3 PDB entries<br>
-<br><b>Homo sapiens</b> (2 PDB entries): <br>
+*<b>Eukaryota</b> (3 PDB entries): <br>
-[[4uis]] <div class="pdb-prints 4uis"></div> 4.4 A resolution. [http://www.ebi.ac.uk/pdbe/entry/emdb/emd-2974 emd-2974]. Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, GAMMA-SECRETASE.<br>
+**<b>Homo sapiens</b> (2 PDB entries): <br>
-<br><b>Enterobacteria phage P22</b> (2 PDB entries): <br>
+***[[3wja]] <div class="pdb-prints 3wja"></div>
-[[2anv]] <div class="pdb-prints 2anv"></div> 1.04 A resolution. <br>
+***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
-<br><b>Enterobacteria phage P21</b> (2 PDB entries): <br>
+***2.548 A resolution
-[[3hdf]] <div class="pdb-prints 3hdf"></div> 1.7 A resolution. <br>
+***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens]
-<br><b>Hevea brasiliensis</b> (2 PDB entries): <br>
+**<b>Columba livia</b> (1 PDB entries): <br>
-[[1kqy]] <div class="pdb-prints 1kqy"></div> 1.92 A resolution. <br>
+***[[1gq2]] <div class="pdb-prints 1gq2"></div>
-<br><b>Escherichia phage T5</b> (2 PDB entries): <br>
+***Title: MALIC ENZYME FROM PIGEON LIVER
-[[2mxz]] <div class="pdb-prints 2mxz"></div> N/A A resolution. <br>
+***2.5 A resolution
-<br><b>Streptococcus phage CP-7</b> (2 PDB entries): <br>
+== Alternative names for NADP-dependent malic enzyme ==
-[[4cvd]] <div class="pdb-prints 4cvd"></div> 1.666 A resolution. <br>
+Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''.
-<br><b>Antheraea mylitta</b> (2 PDB entries): <br>
-[[1iiz]] <div class="pdb-prints 1iiz"></div> 2.4 A resolution. <br>
+== 3D Structures of NADP-dependent malic enzyme ==
-<br><b>Mus musculus</b> (2 PDB entries): <br>
-[[1iak]] <div class="pdb-prints 1iak"></div> 1.9 A resolution. Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.<br>
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-<br><b>Bombyx mori</b> (2 PDB entries): <br>
-[[1gd6]] <div class="pdb-prints 1gd6"></div> 2.5 A resolution. <br>
-<br><b>Streptococcus phage Cp-1</b> (2 PDB entries): <br>
+[[3wja]], [[2aw5]] – hME - human<br />
-[[2j8g]] <div class="pdb-prints 2j8g"></div> 1.69 A resolution. <br>
+[[7x11]], [[7x12]] – hME1 + NADP<br />
-<br><b>Enterobacteria phage T4</b> (2 PDB entries): <br>
+[[8e76]], [[8eyn]] – hME3<br />
-[[1swy]] <div class="pdb-prints 1swy"></div> 1.06 A resolution. <br>
+[[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br />
-<br><b>Enterobacteria phage P1</b> (2 PDB entries): <br>
+[[1gq2]] – ME + NADP - pigeon<br />
-[[1xju]] <div class="pdb-prints 1xju"></div> 1.07 A resolution. <br>
+[[5ou5]] – ME - maize<br />
-<br><b>Enterobacteria phage lambda</b> (2 PDB entries): <br>
-[[1am7]] <div class="pdb-prints 1am7"></div> 2.3 A resolution. <br>
+== References ==
-<br><b>Meretrix lusoria</b> (2 PDB entries): <br>
+<references/>
-[[4pj2]] <div class="pdb-prints 4pj2"></div> 1.24 A resolution. Other macromolecules also in this entry: Putative exported protein, Putative exported protein.<br>
+[[Category:Topic Page]][[Category:PDBe]]
-<br><b>Ruditapes philippinarum</b> (2 PDB entries): <br>
-[[2dqa]] <div class="pdb-prints 2dqa"></div> 1.6 A resolution. <br>
-<br><b>Escherichia coli</b> (2 PDB entries): <br>
-[[2qb0]] <div class="pdb-prints 2qb0"></div> 2.56 A resolution. Other macromolecules also in this entry: Transcription factor ETV6, Transcription factor ETV6.<br>