5eho: Difference between revisions

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-'''Unreleased structure'''
-The entry 5eho is ON HOLD
+==Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach==
+<StructureSection load='5eho' size='340' side='right'caption='[[5eho]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5eho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EHO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5O1:~{N}8-CYCLOHEXYL-~{N}2-[2-METHOXY-4-(1-METHYLPYRAZOL-4-YL)PHENYL]PYRIDO[3,4-D]PYRIMIDINE-2,8-DIAMINE'>5O1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eho OCA], [https://pdbe.org/5eho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eho RCSB], [https://www.ebi.ac.uk/pdbsum/5eho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eho ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
-Authors: Innocenti, P., Woodward, H.L., Solanki, S., Naud, N., Westwood, I.M., Cronin, N., Hayes, A., Roberts, J., Henley, A.T., Baker, R., Faisal, A., Mak, G., Box, G., Valenti, M., De Haven Brandon, A., O'Fee, L., Saville, J., Schmitt, J., Burke, R., van Montfort, R.L.M., Raymaud, F.I., Eccles, S.A., Linardopoulos, S., Blagg, J., Hoelder, S.
+==See Also==
+*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
-Description: Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle kinase 1 (MPS1) Using a Structure-Based Hydridization Approach
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Burke, R]]
+__TOC__
-[[Category: Van Montfort, R.L.M]]
+</StructureSection>
-[[Category: Woodward, H.L]]
+[[Category: Homo sapiens]]
-[[Category: Hoelder, S]]
+[[Category: Large Structures]]
-[[Category: Solanki, S]]
+[[Category: Baker R]]
-[[Category: Innocenti, P]]
+[[Category: Blagg J]]
-[[Category: Hayes, A]]
+[[Category: Box G]]
-[[Category: Blagg, J]]
+[[Category: Burke R]]
-[[Category: Westwood, I.M]]
+[[Category: Cronin N]]
-[[Category: Valenti, M]]
+[[Category: De Haven Brandon A]]
-[[Category: Mak, G]]
+[[Category: Eccles SA]]
-[[Category: Henley, A.T]]
+[[Category: Faisal A]]
-[[Category: Cronin, N]]
+[[Category: Hayes A]]
-[[Category: Raymaud, F.I]]
+[[Category: Henley AT]]
-[[Category: Saville, J]]
+[[Category: Hoelder S]]
-[[Category: De Haven Brandon, A]]
+[[Category: Innocenti P]]
-[[Category: Eccles, S.A]]
+[[Category: Linardopoulos S]]
-[[Category: Box, G]]
+[[Category: Mak G]]
-[[Category: Linardopoulos, S]]
+[[Category: Naud N]]
-[[Category: Schmitt, J]]
+[[Category: O'Fee L]]
-[[Category: O'Fee, L]]
+[[Category: Raymaud FI]]
-[[Category: Faisal, A]]
+[[Category: Roberts J]]
-[[Category: Baker, R]]
+[[Category: Saville J]]
-[[Category: Roberts, J]]
+[[Category: Schmitt J]]
-[[Category: Naud, N]]
+[[Category: Solanki S]]
+[[Category: Valenti M]]
+[[Category: Westwood IM]]
+[[Category: Woodward HL]]
+[[Category: Van Montfort RLM]]