5eh1: Difference between revisions

<StructureSection load='5eh1' size='340' side='right'caption='[[5eh1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[5eh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EH1 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eh1 OCA], [https://pdbe.org/5eh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eh1 RCSB], [https://www.ebi.ac.uk/pdbsum/5eh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eh1 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/INGR2_HUMAN INGR2_HUMAN] Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR2 deficiency;Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR2 deficiency;Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR2 deficiency. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/INGR2_HUMAN INGR2_HUMAN] Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114).<ref>PMID:15356148</ref> <ref>PMID:7615558</ref> <ref>PMID:7673114</ref> <ref>PMID:8124716</ref>  

*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cerny J]]

[[Category: Dohnalek J]]

[[Category: Kolenko P]]

[[Category: Koval T]]

[[Category: Mikulecky P]]

[[Category: Necasova I]]

[[Category: Schneider B]]

[[Category: Zahradnik J]]