5edd: Difference between revisions
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==Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant== | ==Crystal structure of Mycobacterium tuberculosis dUTPase R140K, H145W mutant== | ||
<StructureSection load='5edd' size='340' side='right' caption='[[5edd]], [[Resolution|resolution]] 1.97Å' scene=''> | <StructureSection load='5edd' size='340' side='right'caption='[[5edd]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5edd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EDD OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5edd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EDD FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5edd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5edd OCA], [https://pdbe.org/5edd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5edd RCSB], [https://www.ebi.ac.uk/pdbsum/5edd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5edd ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5edd" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5edd" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[DUTPase 3D structures|DUTPase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Harmat | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Leveles | [[Category: Harmat V]] | ||
[[Category: Lopata | [[Category: Leveles I]] | ||
[[Category: Nagy | [[Category: Lopata A]] | ||
[[Category: Toth | [[Category: Nagy GN]] | ||
[[Category: Vertessy | [[Category: Toth J]] | ||
[[Category: Vertessy GB]] | |||