5ec2: Difference between revisions

<StructureSection load='5ec2' size='340' side='right'caption='[[5ec2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ec2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EC2 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LHV:(2S)-2-HYDROXY-3-METHYLBUTANOIC+ACID'>LHV</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ec2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ec2 OCA], [https://pdbe.org/5ec2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ec2 RCSB], [https://www.ebi.ac.uk/pdbsum/5ec2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ec2 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Streptomyces lividans]]

[[Category: Matulef K]]

[[Category: Valiyaveetil FI]]