5e5q: Difference between revisions

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-'''Unreleased structure'''
-The entry 5e5q is ON HOLD  until Paper Publication
+==Racemic snakin-1 in P21/c==
+<StructureSection load='5e5q' size='340' side='right'caption='[[5e5q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Solanum_tuberosum Solanum tuberosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5Q FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5q OCA], [https://pdbe.org/5e5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5q RCSB], [https://www.ebi.ac.uk/pdbsum/5e5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNAK1_SOLTU SNAK1_SOLTU] Has an antimicrobial activity. Causes a rapid aggregation of both Gram-positive and Gram-negative bacteria, but the antimicrobial activity is not correlated with the capacity to aggregate bacteria.<ref>PMID:9885189</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Proteins from the GASA/snakin superfamily are common in plant proteomes and have diverse functions, including hormonal crosstalk, development, and defense. One 63-residue member of this family, snakin-1, an antimicrobial protein from potatoes, has previously been chemically synthesized in a fully active form. Herein the 1.5 A structure of snakin-1, determined by a novel combination of racemic protein crystallization and radiation-damage-induced phasing (RIP), is reported. Racemic crystals of snakin-1 and quasi-racemic crystals incorporating an unnatural 4-iodophenylalanine residue were prepared from chemically synthesized d- and l-proteins. Breakage of the C-I bonds in the quasi-racemic crystals facilitated structure determination by RIP. The crystal structure reveals a unique protein fold with six disulfide crosslinks, presenting a distinct electrostatic surface that may target the protein to microbial cell surfaces.
-Authors: Yeung, H., Squire, C.J., Yosaatmadja, Y., Panjikar, S., Caradoc-Davies, T.T., Baker, E.N., Harris, P.W.R., Brimble, M.A.
+Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.,Yeung H, Squire CJ, Yosaatmadja Y, Panjikar S, Lopez G, Molina A, Baker EN, Harris PW, Brimble MA Angew Chem Int Ed Engl. 2016 May 4. doi: 10.1002/anie.201602719. PMID:27145301<ref>PMID:27145301</ref>
-Description: Racemic snakin-1 in P21/c
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Yosaatmadja, Y]]
+<div class="pdbe-citations 5e5q" style="background-color:#fffaf0;"></div>
-[[Category: Panjikar, S]]
+== References ==
-[[Category: Brimble, M.A]]
+<references/>
-[[Category: Caradoc-Davies, T.T]]
+__TOC__
-[[Category: Yeung, H]]
+</StructureSection>
-[[Category: Baker, E.N]]
+[[Category: Large Structures]]
-[[Category: Harris, P.W.R]]
+[[Category: Solanum tuberosum]]
-[[Category: Squire, C.J]]
+[[Category: Baker EN]]
+[[Category: Brimble MA]]
+[[Category: Harris PWR]]
+[[Category: Panjikar S]]
+[[Category: Squire CJ]]
+[[Category: Yeung H]]
+[[Category: Yosaatmadja Y]]