5e24: Difference between revisions

<StructureSection load='5e24' size='340' side='right' caption='[[5e24]], [[Resolution|resolution]] 2.14&Aring;' scene=''>

<table><tr><td colspan='2'>[[5e24]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E24 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e24 OCA], [http://pdbe.org/5e24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e24 RCSB], [http://www.ebi.ac.uk/pdbsum/5e24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e24 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity). [[http://www.uniprot.org/uniprot/SUH_DROME SUH_DROME]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Required for neurogenesis in imaginal disks. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Required for transcription of Sim. Also functions independently of Notch pathway, in the development of the bristle sensory organ precursor cell.<ref>PMID:10673509</ref> <ref>PMID:12642500</ref> <ref>PMID:7813798</ref>  [[http://www.uniprot.org/uniprot/HLES_DROME HLES_DROME]] Is a potent antagonist of neurogenic gene activity during sensory organ development. The expression of distinct cell fates by the trichogen (shaft) / tormogen (socket) sister cell pair depends on the level of H activity. A certain threshold level of H activity is required, below which both sister cells adopt the tormogen fate.<ref>PMID:1419850</ref> <ref>PMID:1516831</ref> 

[[Category: Kovall, R A]]

[[Category: Yuan, Z]]

[[Category: Csl]]

[[Category: Hairless]]

[[Category: Notch signaling]]

[[Category: Suppressor of hairless]]

[[Category: Transport-dna binding-dna complex]]