8dvc: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 8dvc is ON HOLD
+==Receptor ShHTL5 from Striga hermonthica in complex with strigolactone agonist GR24==
+<StructureSection load='8dvc' size='340' side='right'caption='[[8dvc]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8dvc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Striga_hermonthica Striga hermonthica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DVC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.638&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TZU:(3R,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methyl)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one'>TZU</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dvc OCA], [https://pdbe.org/8dvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dvc RCSB], [https://www.ebi.ac.uk/pdbsum/8dvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dvc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0M5I297_STRHE A0A0M5I297_STRHE]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Strigolactones (SLs) regulate many aspects of plant development, but ambiguities remain about how this hormone is perceived because SL-complexed receptor structures do not exist. We find that when SL binds the Striga receptor, ShHTL5, a series of conformational changes relative to the unbound state occur, but these events are not sufficient for signalling. Ligand-complexed receptors, however, form internal tunnels that posit an explanation for how SL exits its receptor after hydrolysis.
-Authors: Arellano-Saab, A., Skarina, T., Yim, V., Savchenko, A., Stogios, P.J., McCourt, P.
+Structural analysis of a hormone-bound Striga strigolactone receptor.,Arellano-Saab A, Skarina T, Xu Z, McErlean CSP, Savchenko A, Lumba S, Stogios PJ, McCourt P Nat Plants. 2023 Jun 1. doi: 10.1038/s41477-023-01423-y. PMID:37264151<ref>PMID:37264151</ref>
-Description: Receptor ShHTL5 from Striga hermonthica in complex with strigolactone agonist GR24
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Savchenko, A]]
+<div class="pdbe-citations 8dvc" style="background-color:#fffaf0;"></div>
-[[Category: Stogios, P.J]]
+== References ==
-[[Category: Yim, V]]
+<references/>
-[[Category: Arellano-Saab, A]]
+__TOC__
-[[Category: Mccourt, P]]
+</StructureSection>
-[[Category: Skarina, T]]
+[[Category: Large Structures]]
+[[Category: Striga hermonthica]]
+[[Category: Arellano-Saab A]]
+[[Category: McCourt P]]
+[[Category: Savchenko A]]
+[[Category: Skarina T]]
+[[Category: Stogios PJ]]
+[[Category: Yim V]]